Post-Herpetic Neuralgia

Synonyms:

Post zoster neuralgia VZV:

Diagnosis:

Persistence of the pain of herpes zoster more than 3 months after resolution of the rash.
Zoster-associated pain: the continuum of pain from acute herpes zoster to the development of postherpetic neuralgia.

Treatment:

Best medications:

  • Tricyclic antidepressants:
    • Nortriptyline, amitriptyline, desipramine, and maprotiline
  • Antiepileptics:
    • Gabapentin GBP, pregabalin
  • Opioids:
    • Oxycodone or morphine sulfate sustained release
  • Topical lidocaine patches

Others:

  • Capsiacin topical, but takes longer to act

If the above fail:

  • Consider preservative free methylprednisolone intrathecally

Prevention:

  • Use of antivirals within 72 hours of onset of VZV infection

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