Desmoplastic infantile ganglioglioma (DIG) and desmpolastic infantile astrocytoma


Suggested by MRI and confirmed by pathology (brain biopsy/resection)

Clinical features:

occur in children < 2 years old

Findings on Investigations:


  • Supratentorial, superficial cortical
  • Large cystic lesion with solid nodule, displacing normal brain
  • Enhancing nodule
  • May have dural attachment


May have dural attachment

  • Spindle cells in fascicles or storiform pattern. Large neurons in DIG. Also gemistocyte-like cells
  • Dense reticulin network (reticulin or trichorme stains).

Immunohistochemistry: positive for GFAP, synaptophysin (in ganglion cells),

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