{"id":1739,"date":"2016-04-02T22:19:05","date_gmt":"2016-04-03T04:19:05","guid":{"rendered":"https:\/\/learningneurology.com\/?page_id=1739"},"modified":"2018-10-14T18:08:05","modified_gmt":"2018-10-14T18:08:05","slug":"disseminated-necrotizing-leukoencephalopathy-dnl","status":"publish","type":"post","link":"https:\/\/learningneurology.com\/disseminated-necrotizing-leukoencephalopathy-dnl\/","title":{"rendered":"Disseminated Necrotizing Leukoencephalopathy (DNL)"},"content":{"rendered":"<h4>Synonyms:<\/h4>\n<p>a.k.a. Multifocal necrotizing leukoencephalopathy<\/p>\n<h4>Diagnosis:<\/h4>\n<p>Clinical +MRI +\/-biopsy<br \/>\nOccurs after Radiation therapy and\/or chemotherapy<\/p>\n<h4>Clinical features:<\/h4>\n<p>Encephalopathy<br \/>\nOccurs after Radiation therapy and\/or chemotherapy<\/p>\n<h4>Findings on Investigations:<\/h4>\n<p>CT:<\/p>\n<ul>\n<li>White matter, Periventricular, centrum semiovale. Spares the U fibres<\/li>\n<li>Hypodensity in white matter. Enhancement can occur.<\/li>\n<\/ul>\n<p>MRI:<\/p>\n<ul>\n<li>White matter, Periventricular, centrum semiovale. Spares the U fibres<\/li>\n<li>T2 hyperintensity. Enhancement can occur.<\/li>\n<\/ul>\n<h4>Pathology:<\/h4>\n<p>Necrosis, reactive gliosis, axonal swelling, demyelination,<br \/>\nWhite matter necrosis, necrosis &amp; loss of myelin &amp; axons which may calcify, lipid-laden macrophages.<br \/>\nDue to:<\/p>\n<ul>\n<li>Radiation therapy and\/or chemotherapy<\/li>\n<li>Septic shock<\/li>\n<li>Other insults<\/li>\n<\/ul>\n<h4>Related articles:<\/h4>\n<ul>\n<li><a href=\"https:\/\/learningneurology.com\/approach-cognitive\/\">Approach to cognitive impairment<\/a>, <a href=\"https:\/\/learningneurology.com\/approach-to-acute-confusion-altered-mental-status\/\">approach to acute confusion<\/a>,<\/li>\n<li><a href=\"https:\/\/learningneurology.com\/diseases\/radiation-myelopathy\/\">Radiation myelopathy<\/a>, <a href=\"https:\/\/learningneurology.com\/diseases\/radiation-induced-spinal-cord-hemorrhage\/\">radiation induced spinal cord hemorrhage<\/a>, <a href=\"https:\/\/learningneurology.com\/diseases\/radiation-vasculopathy\/\">radiation vasculopathy<\/a>,<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Synonyms: a.k.a. Multifocal necrotizing leukoencephalopathy Diagnosis: Clinical +MRI +\/-biopsy Occurs after Radiation therapy and\/or chemotherapy Clinical features: Encephalopathy Occurs after Radiation therapy and\/or chemotherapy Findings on Investigations: CT: White matter, Periventricular, centrum semiovale. Spares the U fibres Hypodensity in white matter. Enhancement can occur. MRI: White matter, Periventricular, centrum semiovale. Spares the U fibres T2 &hellip; <a href=\"https:\/\/learningneurology.com\/disseminated-necrotizing-leukoencephalopathy-dnl\/\" class=\"more-link\">Continue reading <span class=\"screen-reader-text\">Disseminated Necrotizing Leukoencephalopathy (DNL)<\/span> <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_publicize_message":"","jetpack_publicize_feature_enabled":true,"jetpack_social_post_already_shared":true,"jetpack_social_options":{"image_generator_settings":{"template":"highway","enabled":false}}},"categories":[32],"tags":[4,5],"jetpack_publicize_connections":[],"jetpack_featured_media_url":"","jetpack_sharing_enabled":true,"jetpack_shortlink":"https:\/\/wp.me\/p71rnx-s3","jetpack-related-posts":[],"_links":{"self":[{"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/posts\/1739"}],"collection":[{"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/comments?post=1739"}],"version-history":[{"count":0,"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/posts\/1739\/revisions"}],"wp:attachment":[{"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/media?parent=1739"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/categories?post=1739"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/learningneurology.com\/wp-json\/wp\/v2\/tags?post=1739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}