Tardive Dyskinesia

Diseases, ,

Diagnosis:

Hyperkinetic movements due to use of dopamine receptor blocking drugs
Types:

  • Orofacial stereotypy
  • Dystonia

Treatment:

  • Stop the offending drug
  • Consider:
    • Valbenazine [KINECT3 RCT]
    • Reserpine
  • If tardive dystonia:
    • Anticholinergics: trihexyphenidyl
    • Botulinum toxin injection
  • If dystonia:
    • Diphenhydramine
  • Benzatropine
  • Consider deep brain stimulation DBS of globus pallidus interna GPi

Related articles:

References:

  1. Hauser RA, Factor SA, Marder SR, et al. KINECT 3: a phase 3 randomized, double-blind, placebo-controlled trial of valbenazine for tardive dyskinesia. Am J Psychiatry 2017;174:476-484. PMID: 28320223. https://doi.org/10.1176/appi.ajp.2017.16091037