Synonyms:
Central nervous system siderosis:
Diagnosis:
MRI:
- T2: dark outlining similar to GRE of all affected structures
- T2 gradient echo GRE: dark outlining to cerebellum, cerebellar folia, VIII cranial nerve & meninges & rest of the brain or spinal cord
- FLAIR: dark outlining similar to GRE of all affected structures
- T1: high signal on CNS surfaces
- T1+C: no enhancement of brain surfaces
- May show source of bleeding
CSF:
- High protein
- Xanthochromia
Clinical features:
- Bilateral sensorineural hearing loss & ataxia
Pathology:
- Thickened brown stained meninges
- Hemosiderin laden macrophages near the surface
- Loss of cerebellar Purkinje cells, gliosis
Treatment:
- Treat source of bleeding