Subacute Sclerosing Panencephalitis (SSPE)


Clinical features, plus EEG

Clinical features:

Previous measles infection. Children or young adults.
Subacute onset of progressive cognitive deficits, behavioural problems, spasticity, rigidity,
Myoclonus, generalised seizures

Findings on Investigations:

EEG: flat with episodic bursts
Anti-measles antibodies
CSF: raised IgG index


Gross: hard brain (gliosis), Microscopic: intracellular (type A) and intracytoplasmic neuronal and glial inclusions

Related articles: