Diagnosis:
Clinical features:
- Hyperthermia, muscle rigidity, abdominal cramping, hypertension, myoclonus, agitation, coma, life-threatening
Investigations to consider:
- FBC, metabolic panel, creatinine, CK
Treatment:
- Discontinue the drug
- Hyperthermia: Active cooling, entubation & muscle relaxants
- Lorazepam intravenously
- 5HT2 antagonist: cyproheptadine orally
- If severe: intensive care & observation