Diagnosis:
Suggested by MRI and confirmed by pathology (brain biopsy/resection)
Findings on Investigations:
Eye, optic nerve, pineal gland
Pathology:
Grossly: White tan mass
Histology:
- Small round blue cells, rosette (Homer-Wright around neuritic processes & Flexner-Wintersteiner around a central lumen), necrosis, frequent mitosis
Immunohistochemistry: NSE, NeuN, synaptophysin
Genetics: RB gene mutation 13q14, germline.