Rathke Cleft Cyst

Diagnosis:

Suggested by MRI and confirmed by pathology (brain biopsy/resection)

Clinical features:

Visual problems, headache, Hypopituitarysm,

Findings on Investigations:

CT:

  • Intrasellar or suprasellar
  • Variable density (based on mucus content)

MRI:

  • Intrasellar or suprasellar
  • T1: cyst is hyperintense
  • T1 +GAD: pituitary enhances, lesion remains hyperintense

Pathology:

Histology:

  • Epithelial lined cavity, cuboidal or columnar epithelium, +/-cilia, serous mucous or gelatinous contents.
  • Occasional squamous metaplasia occurs.

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