WHO grade II
Diagnosis:
Suggested by MRI and confirmed by pathology (brain biopsy/resection)
Findings on Investigations:
Supratentorial. Superficial, may involve meninges i.e. meningocerebral mass. Associated with a cyst.
T1: hyperintense mural nodule. Hypointense cyst
Pathology:
Histology:
- Pleomorphic cells, lipidized cells i.e. Lipid-laden astrocytes, cellular atypia, spindle cells, multinucleated giant cells. Xanthomatous (foamy/clear) astrocytes.
- Often, eosinphilic granular bodies (PAS positive), Lymphocytic infiltrates may occur.
- Silver impregnations: cells surrounded by reticulin network
- Immunohistochemistry: GFAP positive, S100 positive
Treatment:
Surgical resection