Osmotic Demyelination Syndrome

Synonyms:

central pontine myelinolysis, and extrapontine myelinolysis

Diagnosis:

Clinical features plus MRI plus history of rapid change (increase or decrease) in sodium levels

Clinical features:

Encephalopathy, coma, quadriparesis, upper motor neuron signs, dysphagia

Findings on Investigations:

MRI :

  • T2 : high signal in pons, basal ganglia, thalami
  • FLAIR: high signal in pons, basal ganglia, thalami

Treatment:

Supportive care

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