Nonparaneoplastic Autoimmune Limibic Encephalitis


Clinical features plus antibodies and negative investigations for neoplastic disease

Clinical features:

Subacute impairment, seizures, temporal lobe seizures & hallucinations,

Findings on Investigations:

Associated antibodies:

  • VGKC, voltage-gated potassium channels (Kv1) antibodies:
  • These are positive in patients with limbic encephalitis, Morovan’s syndrome. These have differnet targets.
  • Lgi1: leucine-rich, glioma inactivated 1 protein, a subtype of VGKC found in limbic encephalitis.
  • Caspr2: contactin-associated protein-antibody-2, a subtype of VGKC found in Morovan’s syndrome
  • anti-NMDA receptor antibodies

MRI: may show medial temporal lobe FLAIR hyperintensity & enhancement

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