Neuroleptic Malignant Syndrome

Diagnosis:

Clinical:

  • Hyperpyrexia +autonomic instability + muscle rigidity +tachycardia +fluctuation of consciousness

Investigations to consider:

  • FBC: leukocytosis, LFTs: AST & ALT are high, U&E, creatinine
  • Creatine kinase: high,, plasma myoglobin: high
  • Urinalysis for myoglobin: myoglobinuria

Treatment:

  • Discontinuing the offending drug/drugs
  • Cooling
  • Dantrolene
  • Dopamine agonist e.g. bromocriptine

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