Neurofibroma

Diagnosis:

Suggested by MRI and confirmed by pathology (brain biopsy/resection)

Pathology:

Histology:

  • Spindle cell tumor, densely packed, fascicular appearance. Interstitial axons (sliver impregnation or neurofilament)

Immunohistochemistry: positive for= S100. Neurofilament positive interstitial axons.

Findings on Investigations:

Plexiform type is almost always associated with neurofibromatosis type I
MRI:

  • Widened neural foramina. Erosion of the pedicle. Usually dorsal spinal nerve roots

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