Diagnosis:
This is a clinical diagnosis supported by findings on polysomnogram
Clinical features:
Daytime hypersomnolance, wake up refreshed
Cataplexy (sudden loss of muscle tone triggered by emotional situations)
Hypnogogic & hypnopopic hallucinations
Sleep paralysis (patient wakes from sleep but tone is still absent, last 10min)
Findings on investigations:
MSLT (multiple sleep latency test): decreased latency for REM sleep i.e. <8min +2 sleep-onset REM periods
CSF hypocretin-1 (formerly orexin A): low in patients with cataplexy, <110 pg/ml
Treatment:
Amfetamines: Dextroamfetamine P.O.
Antidepressants for cataplexy