WHO grade I
Diagnosis:
Suggested by MRI and confirmed by pathology (brain biopsy/resection)
Findings on Investigations:
MRI: Intracortical lesions, commonly in the temporal lobe, may have a small cystic component
Clinical features:
Associated with intractable seizures in some cases
Pathology:
Histology: Nodular or multinodular. Mucin rich cortical nodules
Oligodendroglial-like areas (halos without satellitosis) and neurocytic areas. ‘specific glioneuronal element’: oligodendroglial-like cells with axons around microcystic spaces with ganglion cells. Floating neurons= ganglion cells in a pool of mucin
Dysplastic adjacent cortex. Calcifications & cysts may occur.
Immunohistochemistry: synaptophysin positive, S100 oligodendroglial-like cells positive, GFAP negative, MIB low.
Treatment:
Surgical resection
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