WHO grade II
Diagnosis:
Suggested by MRI and confirmed by pathology (brain biopsy/resection)
Findings on Investigations:
Ill defined, homogenous lesion, cystic degeneration may occur. Usually non-enhancing. Enhancement suggests anaplasia
CT: hypodense. May be unapparent.
T2/FLAIR: high signal
Pathology:
Histology:
- Nuclear atypia, extremely rare mitosis, no microvascular proliferation, no necrosis
- Variants: fibrillary, gemistocytic, protoplasmic
- FISH: deletion of 1q & 19p.
Treatment:
Surgery
Consider Chemotherapy:
- Temozolamide TMZ if 1p/19q codeletion (200 mg/m2/day for 5 consecutive days, repeated every 28 days).