Coeliac Disease Neuropathy

Synonyms:

a.k.a. gluten neuropathy

Diagnosis:

Diagnosis of Coeliac disease or serology positive for coeliac disease, plus clinical or electrodiagnostic neuropathy and exclusion of other causes

Clinical features:

Different patterns: sensorimotor neuropathy >mononeuropathy multiplex >motor neuropathy >small fibre neuropathy.

Findings on investigations:

+NCS/EMG:

  • Axonal neuropathy pattern, different patterns (sensorimotor neuropathy >mononeuropathy multiplex >motor neuropathy >small fibre neuropathy)

Other tests:

  • Associated with HLA-DQ2, HLA-DQ8

Pathology:

Epineurium: lymphocytic infiltrate. Endoneurium: lymphocytic infiltrate. Wallerian degeneration.

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