Anti-sulfatide Neuropathy

Synonyms:

a.k.a. anti-chondroitin sulfate neuropathy:

Diagnosis:

The diagnosis is made based on clinical features supported by electrodiagnostic tests and antibodies

Clinical features:

Polyneuropathy (sensory, or sensorimotor, sensory>motor), ataxia may occur,

Findings on investigations:

Anti-sulfatide antibody (a.k.a. anti-chondroitin sulfate): positive, > 1:1000 titre
SPEP +IFE: usually have monoclonal IgM
NCS/EMG:

  • Mainly demyelinating pattern with secondary axonal loss

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