Synonyms:
a.k.a. gait ataxia and polyneuropathy GAPN
Diagnosis:
Clinical features:
Late onset 70 year olds, gait ataxia (wide based with falls) and polyneuropathy (sensorimotor, sensory>motor, impaired proprioception)
Anti-GALOP (IgM against central myelin antigen a.k.a. galopin): positive,
SPEP +IFE: monoclonal IgM
Treatment:
Intravenous immunoglobulin IVIG
cyclophosphamide